SCHISANDRA CHINENSIS

Schisandra Chinensis (SC) is frequently used in China, Korea, and Japan as a tonic for kidney and a treatment for alleviating various symptoms of cognitive deficits and facilitating learning and memory for thousands of years. Recent experience from clinic and laboratory supported the notion that SC was safe and effective in improving cognitive function and reversing cycloheximide-induced amnesia in rats. And also, lignans like Schizarin A, B, C, D, and E were reported to exhibit the antioxidant activity, and some other lignans like gomisin A, C, D, and G along with gallotannins showed excellent inhibitory effects for AChE in several compounds. The SC extract has the potential to reduce AChE activity and relieve the oxidative damage both in vivo and in vitro. Through the assays in PC12 cells and the Alzheimer disease mouse model induced by scopolamine, SC extract exhibited potent neuroprotective effects linked to antioxidative mechanisms. Moreover, based on the determination activity of AChE, the effects of SC may be partly attributed to its potential to inhibit the activity of AChE. Therefore, SC extract could serve as a multifunctional therapeutic remedy for the treatment of Alzheimer disease. The treatment with SC extract was potentially an effective and simple strategy to improve learning and memory abilities in the elderly and may be a feasible method to prevent the development of Alzheimer disease.

PUBLISHED ARTICLES :

** Biomed Pharmacother.2018 Jan;97:958-968.doi: 10.1016/j.biopha.2017.10.145.

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

** Molecules. 2018 Apr 10;23(4):870.doi: 10.3390/molecules23040870.

Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ1-42-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells

** Oxid Med Cell Longev. 2022 Jul 11;2022:6362617.doi: 10.1155/2022/6362617. eCollection 2022.

Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis

** Evid Based Complement Alternat Med. 2020 Feb 20;2020:2804849.doi: 10.1155/2020/ 2804849.

In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer's Disease

** Indian J Pharmacol.2020 Mar-Apr;52(2):94-101.doi:10.4103/ijp.IJP_515_19.Epub 2020 Jun 3

Network pharmacology-based study on the mechanism of Schisandra chinensis for treating Alzheimer's disease

** J Ethnopharmacol.2019 Jun 12;237:354-365.doi:10.1016/j.jep.2019.02.046.Epub 2019 Mar 4.

Polysaccharide of Schisandra Chinensis Fructus ameliorates cognitive decline in a mouse model of Alzheimer's disease

** Int J Mol Sci. 2018 Jul 6;19(7):1970.doi: 10.3390/ijms19071970.

Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases

** Molecules. 2019 Mar 27;24(7):1203.doi: 10.3390/molecules24071203.

Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS

** PLoS One. 2016 Apr 1;11(4):e0152772.doi: 10.1371/journal.pone.0152772. eCollection 2016.

Total Lignans of Schisandra chinensis Ameliorates Aβ1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells