Polygala Tenuifolia Willd. Yuan Zhi olarak da bilinen (Polygalaceae), triterpen saponinler, onjisaponinler ve poligalasaponinler ile zenginleştirildiği bildirilmiş (Jin ve ark. 2014) ve merkezi sinir sistemi üzerinde de koruyucu etkiler göstermekte ve sıklıkla hafıza bozukluğu, uykusuzluk ve nevrasteni tedavisinde kullanılmaktadır (Zhang ve ark. 2016). Polygala Tenuifolia'nın farmakolojik olarak aktif bileşenleri olan poligalasaponin XXXII (PGS 32), tenuifolin, poligalakik asit ve senegenin (tenuigenin) dahil olmak üzere poligalasaponinlerin, anti-β-amiloid (Ab) agregasyon (Jia ve ark. 2004; Park ve ark. 2019), anti-Tau (Xu ve ark. 2012), anti-inflamasyon (Cheong ve ark. 2011 ; Wang ve ark. 2017), antioksidan (Zhang ve ark. 2011), merkezi kolinerjik sistemi güçlendiren anti-nöronal apoptoz (Li ve ark. 2015), nöronal proliferasyonu desteklemesi gibi (Park ve ark. 2008; Zhu ve ark. 2016) Alzheimer Hastalığı ile ilişkili çoklu nöroprotektif potansiyele sahip olduğu gösterilmiştir.
KONU İLE İLGİLİ ÇIKMIŞ YAYINLAR :
** BMC Complement Med Ther. 2021 Oct 25;21(1):267.doi: 10.1186/s12906-021-03437-5.
Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
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Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons
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Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia
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Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice
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Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats
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Polygala tenuifolia: a source for anti-Alzheimer's disease drugs
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Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007183/pdf/aps2009112a.pdf** Front Psychiatry. 2021 Dec 17;12:688703.doi: 10.3389/fpsyt.2021.688703.
Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance
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Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats
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The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724108/pdf/12906_2016_Article_1006.pdf